Radiation Cancer Treatment in Less than a Second Feasible -Study 


On  January 11, 2020. By Sola Ogundipe

Cancer patients may one day be able to get their entire course of radiation therapy in less than a second rather than coming in for treatment over the course of several weeks, according to researchers in the Abramson Cancer Center of the University of Pennsylvania.

The researchers who have taken the first steps toward making it a reality, explain how they did it in a new report published in the International Journal of Radiation Oncology, Biology, and Physics.

Ginna Crochets IMG-20190728-WA0000

They used proton radiation to generate the dosage needed to theoretically give a cancer patient their entire course of radiotherapy in one rapid treatment known as FLASH radiotherapy.

It’s an experimental paradigm that could represent a sea change for the world of oncology in the future.

In the study, researchers also found FLASH demonstrated the same effect on tumours as traditional photon radiation while sparing healthy tissue due to the shorter exposure time.

“It is the first time anyone has published findings that demonstrate the feasibility of using protons—rather than electrons—to generate FLASH doses, with an accelerator currently used for clinical treatments,” said the study’s co-senior author Dr James M. Metz, director of the Roberts Proton Therapy Center and chair of Radiation Oncology.

Metz noted that other research teams have generated similar doses using electrons, which do not penetrate deep enough into the body to be clinically useful as a cancer treatment for internal tumours.

Other groups have tried the approach with conventional photons, but currently available treatment devices do not have the ability to generate the necessary dosage. This study shows, that with technical modifications, the currently available accelerators for protons can achieve FLASH doses with the biologic effects today.

The key for the Penn team was the ability to generate the dose with protons, and even in that setting, researchers had to specially develop the tools needed to effectively and accurately measure radiation doses, since the standard detectors were quickly saturated due to the high levels of radiation.

The Roberts Proton Therapy Center includes a dedicated research room to run experiments like these, allowing investigators to use photon and proton radiation side-by-side just feet from the clinic. It’s one of the few facilities in the world with those unique features, and Metz said this infrastructure is what made Penn’s FLASH experiments possible.

“We’ve been able to develop specialized systems in the research room to generate FLASH doses, demonstrate that we can control the proton beam, and perform a large number of experiments to help us understand the implications of FLASH radiation that we simply could not have done with a more traditional research setup,” Metz said.

The researchers are already beginning to optimize how they would use this down the road for clinical trials, including taking the necessary steps to translate the ability from the research room to a clinical space, as well as designing a delivery system for FLASH in humans.

Co-senior authors on the study are Dr. Constantinos Koumenis, the Richard H. Chamberlain Professor of Research Oncology, and Dr. Keith A. Cengel, an associate professor of Radiation Oncology, both in Penn’s Perelman School of Medicine.


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s